Quantitative Synaptology
in Space and Time

start_rizzoli

WELCOME to the homepage
of Prof. Dr. Silvio O. Rizzoli

The diffraction barrier has been particularly problematic for imaging synaptic vesicles, which are among the smallest known organelles (30-50 nm in diameter). They are located in small areas in the synapses (about 1 micron in diameter).

Our group takes advantage of increase imaging resolution provided by different types of microscopy to investigate synaptic vesicle function, with an emphasis on synaptic vesicle recycling. Since STED microscopy also allows imaging of protein domains, the group aims at studying the patterning of protein domains in the synapse, in order to understand its molecular architecture.

Research

Read more about our work

Members

Who we are

Publications

Have a look at our
latest publications

Major projects

ULTRARESOLUTION

ULTRARESOLUTION Beyond super-resolution: ultra-resolution imaging provides solutions for synapse physiology and brain pathology ERC Synergy Grant 2020 01.06.2021-31.05.2027 Neurons contain hundreds of specialized proteins, whose

READ MORE

Imageomics

Imageomics Future and Emerging Technologies (FET-OPEN) 2020:  High-throughput imaging of proteins using nanobodies The conventional detection of proteins by imaging employs fluorophores or antibodies directed

READ MORE

Live STED Microscopy

Major Projects LIVE STED MICROSCOPY The project was initiated in December 2007, and focuses on the application of super-resolution techniques in living preparations. In line

READ MORE

The Neuron Nanomap

Research & Background THE NEURON NANOMAP In this project, which has started in April 2014, we generate a super-resolution image – a nanomap – of

READ MORE