2023
A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy.
Queiroz Zetune Villa Real K, Mougios N, Rehm R, Sograte-Idrissi S, Albert L, Rahimi AM, Maidorn M, Hentze J, Martínez-Carranza M, Hosseini H, Saal KA, Oleksiievets N, Prigge M, Tsukanov R, Stenmark P, Fornasiero EF, Opazo F.
Small Methods. 2023 Jul 8:e2300218. doi: 10.1002/smtd.202300218. Online ahead of print.
Generalizing the definition of protein turnover to out-of-equilibrium conditions.
Fornasiero EF.
Bioessays. 2023 Jun;45(6):e2300059. doi: 10.1002/bies.202300059. Epub 2023 Apr 12.
Toward a hypothesis-free understanding of how phosphorylation dynamically impacts protein turnover.
Li W, Salovska B, Fornasiero EF, Liu Y.
Proteomics. 2023 Feb;23(3-4):e2100387. doi: 10.1002/pmic.202100387. Epub 2022 Dec 7.
The PPAR-γ Agonist Pioglitazone Modulates Proliferation and Migration in HUVEC, HAOSMC and Human Arteriovenous Fistula-Derived Cells.
Ciavarella C, Motta I, Vasuri F, Palumbo T, Lisi AP, Costa A, Astolfi A, Valente S, Versura P, Fornasiero EF, Mauro R, Gargiulo M, Pasquinelli G.
Int J Mol Sci. 2023 Feb 23;24(5):4424. doi: 10.3390/ijms24054424.
2022
Towards a hypothesis-free understanding of how Phosphorylation dynamically impacts protein turnover.
Li W, Salovska B, Fornasiero EF, Liu Y.
Proteomics. 2022 Nov 24:e2100387. doi: 10.1002/pmic.202100387. Online ahead of print.
Determining and interpreting protein lifetimes in mammalian tissues.
Fornasiero EF, Savas JN.
Trends Biochem Sci. 2022 Sep 23:S0968-0004(22)00236-5. doi: 10.1016/j.tibs.2022.08.011. Online ahead of print.
IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.
Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I.
Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2121040119. doi: 10.1073/pnas.2121040119. Epub 2022 Aug 9.
Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration.
Kluever V, Russo B, Mandad S, Kumar NH, Alevra M, Ori A, Rizzoli SO, Urlaub H, Schneider A, Fornasiero EF.
Sci Adv. 2022 May 20;8(20):eabn4437. doi: 10.1126/sciadv.abn4437. Epub 2022 May 20.
A Reliable Approach for Revealing Molecular Targets in Secondary Ion Mass Spectrometry.
Li F, Fornasiero EF, Dankovich TM, Kluever V, Rizzoli SO.
Int J Mol Sci. 2022 Apr 21;23(9):4615. doi: 10.3390/ijms23094615.
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Centrosome-dependent microtubule modifications set the conditions for axon formation.
Meka DP, Kobler O, Hong S, Friedrich CM, Wuesthoff S, Henis M, Schwanke B, Krisp C, Schmuelling N, Rueter R, Ruecker T, Betleja E, Cheng T, Mahjoub MR, Soba P, Schlüter H, Fornasiero EF, Calderon de Anda F.
Cell Rep. 2022 Apr 19;39(3):110686. doi: 10.1016/j.celrep.2022.110686.
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2021
Principles of brain aging: Status and challenges of modeling human molecular changes in mice.
Kluever V, Fornasiero EF.
Ageing Res Rev. 2021 Sep 20;72:101465. doi: 10.1016/j.arr.2021.101465. Online ahead of print.
Influence of Subcellular Localization and Functional State on Protein Turnover.
Yousefi R, Jevdokimenko K, Kluever V, Pacheu-Grau D, Fornasiero EF.
Cells. 2021 Jul 10;10(7):1747. doi: 10.3390/cells10071747.
Brain Long Noncoding RNAs: Multitask Regulators of Neuronal Differentiation and Function.
Keihani S, Kluever V, Fornasiero EF.
Molecules. 2021 Jun 28;26(13):3951. doi: 10.3390/molecules26133951.
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Monitoring mitochondrial translation in living cells.
Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D.
EMBO Rep. 2021 Apr 7;22(4):e51635. doi: 10.15252/embr.202051635. Epub 2021 Feb 15.
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Protein Phosphorylation in Depolarized Synaptosomes: Dissecting Primary Effects of Calcium from Synaptic Vesicle Cycling.
Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R.
Mol Cell Proteomics. 2021 Feb 12;20:100061. doi: 10.1016/j.mcpro.2021.100061. Online ahead of print.
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In Vivo Protein Lifetime Measurements Across Multiple Organs in the Zebrafish.
Mandad S, Kracht G, Fornasiero EF.
Methods Mol Biol. 2021;2218:291-302. doi: 10.1007/978-1-0716-0970-5_23.
Global and Site-Specific Effect of Phosphorylation on Protein Turnover.
Wu C, Ba Q, Lu D, Li W, Salovska B, Hou P, Mueller T, Rosenberger G, Gao E, Di Y, Zhou H, Fornasiero EF, Liu Y.
Dev Cell. 2021 Jan 11;56(1):111-124.e6. doi: 10.1016/j.devcel.2020.10.025. Epub 2020 Nov 24.
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NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover.
Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO.
BMC Mol Cell Biol. 2021 Jan 11;22(1):5. doi: 10.1186/s12860-020-00339-1.
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2020
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO.
EMBO J. 2020 Aug 17;39(16):e104596. doi: 10.15252/embj.2020104596. Epub 2020 Jul 6.
A Comparative Analysis of the Mobility of 45 Proteins in the Synaptic Bouton.
Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO.
EMBO J. 2020 Jul 6:e104596. doi: 10.15252/embj.2020104596. Online ahead of print.
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A Nanobody-Based Fluorescent Reporter Reveals Human α-Synuclein in the Cell Cytosol.
Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, Becker S, Rizzoli SO, Basmanav FB, Opazo F.
Nat Commun. 2020 Jun 1;11(1):2729. doi: 10.1038/s41467-020-16575-0.
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2019
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.
Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gärtner A, Kügler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF.
Sci Adv. 2019 Dec 18;5(12):eaay2670. doi: 10.1126/sciadv.aay2670. eCollection 2019 Dec.
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A mass spectrometry workflow for measuring protein turnover rates in vivo.
Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF.
Nat Protoc. 2019 Nov 4. doi: 10.1038/s41596-019-0222-y. [Epub ahead of print]
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Pathological changes are associated with shifts in the employment of synonymous codons at the transcriptome level.
Fornasiero EF, Rizzoli SO.
BMC Genomics. 2019 Jul 9;20(1):566. doi: 10.1186/s12864-019-5921-9.
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2018
The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF.
Sci Rep. 2018 Nov 15;8(1):16913. doi: 10.1038/s41598-018-35277-8.
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Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.
Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO.
Nat Commun. 2018 Oct 12;9(1):4230. doi: 10.1038/s41467-018-06519-0.
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Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO.
EMBO J. 2018 Aug 1;37(15). pii: e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27.
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2017
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.
Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M.
Sci Transl Med. 2017 Dec 6;9(419). pii: eaam7816. doi: 10.1126/scitranslmed.aam7816.
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Synapsin I deletion reduces neuronal damage and ameliorates clinical progression of experimental autoimmune encephalomyelitis.
Guarnieri FC, Bellani S, Yekhlef L, Bergamaschi A, Finardi A, Fesce R, Pozzi D, Monzani E, Fornasiero EF, Matteoli M, Martino G, Furlan R, Taverna S, Muzio L, Valtorta F.
Brain Behav Immun. 2017 Oct 21. pii: S0889-1591(17)30474-9. doi: 10.1016/j.bbi.2017.10.018.
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2015
Super-resolution imaging for cell biologists: concepts, applications, current challenges and developments.
Fornasiero EF, Opazo F.
Bioessays. 2015 Apr;37(4):436-51. doi: 10.1002/bies.201400170. Epub 2015 Jan 12.
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Cadherins as regulators of neuronal polarity.
Gärtner A, Fornasiero EF, Dotti CG.
Cell Adh Migr. 2015;9(3):175-82. doi: 10.4161/19336918.2014.983808. Epub 2014 Nov 14. Review.
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2014
Distinct temporal hierarchies in membrane and cytoskeleton dynamics precede the morphological polarization of developing neurons.
Gärtner A, Fornasiero EF, Valtorta F, Dotti CG.
J Cell Sci. 2014 Oct 15;127(Pt 20):4409-19. doi: 10.1242/jcs.149815. Epub 2014 Aug 15.
2012
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
Fornasiero EF, Raimondi A, Guarnieri FC, Orlando M, Fesce R, Benfenati F, Valtorta F.
J Neurosci. 2012 Aug 29;32(35):12214-27. doi: 10.1523/JNEUROSCI.1554-12.2012.
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N-cadherin: a new player in neuronal polarity.
Gärtner A, Fornasiero EF, Dotti CG.
Cell Cycle. 2012 Jun 15;11(12):2223-4. doi: 10.4161/cc.20797. Epub 2012 Jun 15. No abstract available.
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N-cadherin specifies first asymmetry in developing neurons.
Gärtner A*, Fornasiero EF*, Munck S, Vennekens K, Seuntjens E, Huttner WB, Valtorta F, Dotti CG.
*equal first authors
EMBO J. 2012 Feb 21;31(8):1893-903. doi: 10.1038/emboj.2012.41.
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2011
Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.
Perlini LE, Botti F, Fornasiero EF, Giannandrea M, Bonanomi D, Amendola M, Naldini L, Benfenati F, Valtorta F.
J Cell Sci. 2011 Nov 1;124(Pt 21):3643-53. doi: 10.1242/jcs.086223. Epub 2011 Nov 1.
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The synapsins: multitask modulators of neuronal development.
Valtorta F, Pozzi D, Benfenati F, Fornasiero EF.
Semin Cell Dev Biol. 2011 Jun;22(4):378-86. doi: 10.1016/j.semcdb.2011.07.008. Epub 2011 Jul 20. Review.
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2010
QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ.
Henriques R, Lelek M, Fornasiero EF, Valtorta F, Zimmer C, Mhlanga MM.
Cell Mol Life Sci. 2010 May;67(9):1383-96. doi: 10.1007/s00018-009-0227-8. Epub 2009 Dec 25. Review.
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The role of synapsins in neuronal development.
Fornasiero EF, Bonanomi D, Benfenati F, Valtorta F.
Mol Microbiol. 2009 Jan;71(2):461-77. doi: 10.1111/j.1365-2958.2008.06538.x. Epub 2008 Nov 19.
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2008
Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones.
Bonanomi D*, Fornasiero EF*, Valdez G, Halegoua S, Benfenati F, Menegon A, Valtorta F.
*equal first authors
J Cell Sci. 2008 Nov 15;121(Pt 22):3757-69. doi: 10.1242/jcs.033803. Epub 2008 Oct 21.
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2007
Role of calcineurin in nicotine-mediated locomotor sensitization.
Addy NA, Fornasiero EF, Stevens TR, Taylor JR, Picciotto MR.
J Neurosci. 2007 Aug 8;27(32):8571-80.
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