Eugenio F. Fornasiero
Publications of Eugenio F. Fornasiero
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning.
Protocol for SUM-PAINT spatial proteomic imaging generating neuronal architecture maps in rat hippocampal neurons.
Unterauer EM, Schentarra EM, Jevdokimenko K, Boushehri SS, Marr C, Opazo F, Fornasiero EF, Jungmann R.
STAR Protoc. 2025 Mar 21;6(1):103637. doi: 10.1016/j.xpro.2025.103637. Epub 2025 Mar 5.
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions.
Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models.
An Extensive Atlas of Proteome and Phosphoproteome Turnover Across Mouse Tissues and Brain Regions.
The DNA-PAINT palette: a comprehensive performance analysis of fluorescent dyes.
Steen PR, Unterauer EM, Masullo LA, Kwon J, Perovic A, Jevdokimenko K, Opazo F, Fornasiero EF, Jungmann R.
Nat Methods. 2024 Sep;21(9):1755-1762. doi: 10.1038/s41592-024-02374-8. Epub 2024 Aug 7.
Morphological correlates of synaptic protein turnover in the mouse brain.
Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations.
DʼEste E, Lukinavičius G, Lincoln R, Opazo F, Fornasiero EF.
Trends Cell Biol. 2024 Aug;34(8):671-684. doi: 10.1016/j.tcb.2023.12.001. Epub 2024 Jan 5.
Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain.
Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, Fornasiero EF, Jungmann R.
Cell. 2024 Mar 28;187(7):1785-1800.e16. doi: 10.1016/j.cell.2024.02.045.
Protocol for differential multi-omic analyses of distinct cell types in the mouse cerebral cortex.
Using graphs and charts in scientific figures.
Age-dependent structural reorganization of utricular ribbon synapses.
Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Gonzalez PA, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C.
Front Cell Dev Biol. 2023 Aug 10;11:1178992. doi: 10.3389/fcell.2023.1178992. eCollection 2023.
A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy.
Generalizing the definition of protein turnover to out-of-equilibrium conditions.
Toward a hypothesis-free understanding of how phosphorylation dynamically impacts protein turnover.
The PPAR-γ Agonist Pioglitazone Modulates Proliferation and Migration in HUVEC, HAOSMC and Human Arteriovenous Fistula-Derived Cells.
Determining and interpreting protein lifetimes in mammalian tissues.
Towards a hypothesis-free understanding of how Phosphorylation dynamically impacts protein turnover.
Determining and interpreting protein lifetimes in mammalian tissues.
IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.
Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration.
A Reliable Approach for Revealing Molecular Targets in Secondary Ion Mass Spectrometry.
Centrosome-dependent microtubule modifications set the conditions for axon formation.
Principles of brain aging: Status and challenges of modeling human molecular changes in mice.
Influence of Subcellular Localization and Functional State on Protein Turnover.
Brain Long Noncoding RNAs: Multitask Regulators of Neuronal Differentiation and Function.
Keihani S, Kluever V, Fornasiero EF.
Molecules. 2021 Jun 28;26(13):3951. doi: 10.3390/molecules26133951.
Monitoring mitochondrial translation in living cells.
Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D.
EMBO Rep. 2021 Apr 7;22(4):e51635. doi: 10.15252/embr.202051635. Epub 2021 Feb 15.
Protein Phosphorylation in Depolarized Synaptosomes: Dissecting Primary Effects of Calcium from Synaptic Vesicle Cycling.
Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R.
Mol Cell Proteomics. 2021 Feb 12;20:100061. doi: 10.1016/j.mcpro.2021.100061. Online ahead of print.
In Vivo Protein Lifetime Measurements Across Multiple Organs in the Zebrafish.
Global and Site-Specific Effect of Phosphorylation on Protein Turnover.
Wu C, Ba Q, Lu D, Li W, Salovska B, Hou P, Mueller T, Rosenberger G, Gao E, Di Y, Zhou H, Fornasiero EF, Liu Y.
Dev Cell. 2021 Jan 11;56(1):111-124.e6. doi: 10.1016/j.devcel.2020.10.025. Epub 2020 Nov 24.
NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover.
Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO.
BMC Mol Cell Biol. 2021 Jan 11;22(1):5. doi: 10.1186/s12860-020-00339-1.
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
A Comparative Analysis of the Mobility of 45 Proteins in the Synaptic Bouton.
Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO.
EMBO J. 2020 Jul 6:e104596. doi: 10.15252/embj.2020104596. Online ahead of print.
A Nanobody-Based Fluorescent Reporter Reveals Human α-Synuclein in the Cell Cytosol.
Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, Becker S, Rizzoli SO, Basmanav FB, Opazo F.
Nat Commun. 2020 Jun 1;11(1):2729. doi: 10.1038/s41467-020-16575-0.
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.
Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gärtner A, Kügler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF.
Sci Adv. 2019 Dec 18;5(12):eaay2670. doi: 10.1126/sciadv.aay2670. eCollection 2019 Dec.
A mass spectrometry workflow for measuring protein turnover rates in vivo.
Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF.
Nat Protoc. 2019 Nov 4. doi: 10.1038/s41596-019-0222-y. [Epub ahead of print]
Pathological changes are associated with shifts in the employment of synonymous codons at the transcriptome level.
Fornasiero EF, Rizzoli SO.
BMC Genomics. 2019 Jul 9;20(1):566. doi: 10.1186/s12864-019-5921-9.
The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF.
Sci Rep. 2018 Nov 15;8(1):16913. doi: 10.1038/s41598-018-35277-8.
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.
Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO.
Nat Commun. 2018 Oct 12;9(1):4230. doi: 10.1038/s41467-018-06519-0.
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO.
EMBO J. 2018 Aug 1;37(15). pii: e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27.
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.
Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M.
Sci Transl Med. 2017 Dec 6;9(419). pii: eaam7816. doi: 10.1126/scitranslmed.aam7816.
Synapsin I deletion reduces neuronal damage and ameliorates clinical progression of experimental autoimmune encephalomyelitis.
Guarnieri FC, Bellani S, Yekhlef L, Bergamaschi A, Finardi A, Fesce R, Pozzi D, Monzani E, Fornasiero EF, Matteoli M, Martino G, Furlan R, Taverna S, Muzio L, Valtorta F.
Brain Behav Immun. 2017 Oct 21. pii: S0889-1591(17)30474-9. doi: 10.1016/j.bbi.2017.10.018.
Super-resolution imaging for cell biologists: concepts, applications, current challenges and developments.
Fornasiero EF, Opazo F.
Bioessays. 2015 Apr;37(4):436-51. doi: 10.1002/bies.201400170. Epub 2015 Jan 12.
Cadherins as regulators of neuronal polarity.
Gärtner A, Fornasiero EF, Dotti CG.
Cell Adh Migr. 2015;9(3):175-82. doi: 10.4161/19336918.2014.983808. Epub 2014 Nov 14. Review.
Distinct temporal hierarchies in membrane and cytoskeleton dynamics precede the morphological polarization of developing neurons.
Gärtner A, Fornasiero EF, Valtorta F, Dotti CG.
J Cell Sci. 2014 Oct 15;127(Pt 20):4409-19. doi: 10.1242/jcs.149815. Epub 2014 Aug 15.
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
Fornasiero EF, Raimondi A, Guarnieri FC, Orlando M, Fesce R, Benfenati F, Valtorta F.
J Neurosci. 2012 Aug 29;32(35):12214-27. doi: 10.1523/JNEUROSCI.1554-12.2012.
N-cadherin: a new player in neuronal polarity.
Gärtner A, Fornasiero EF, Dotti CG.
Cell Cycle. 2012 Jun 15;11(12):2223-4. doi: 10.4161/cc.20797. Epub 2012 Jun 15. No abstract available.
N-cadherin specifies first asymmetry in developing neurons.
Gärtner A*, Fornasiero EF*, Munck S, Vennekens K, Seuntjens E, Huttner WB, Valtorta F, Dotti CG.
*equal first authors
EMBO J. 2012 Feb 21;31(8):1893-903. doi: 10.1038/emboj.2012.41.
Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.
Perlini LE, Botti F, Fornasiero EF, Giannandrea M, Bonanomi D, Amendola M, Naldini L, Benfenati F, Valtorta F.
J Cell Sci. 2011 Nov 1;124(Pt 21):3643-53. doi: 10.1242/jcs.086223. Epub 2011 Nov 1.
The synapsins: multitask modulators of neuronal development.
Valtorta F, Pozzi D, Benfenati F, Fornasiero EF.
Semin Cell Dev Biol. 2011 Jun;22(4):378-86. doi: 10.1016/j.semcdb.2011.07.008. Epub 2011 Jul 20. Review.
QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ.
Henriques R, Lelek M, Fornasiero EF, Valtorta F, Zimmer C, Mhlanga MM.
Cell Mol Life Sci. 2010 May;67(9):1383-96. doi: 10.1007/s00018-009-0227-8. Epub 2009 Dec 25. Review.
The role of synapsins in neuronal development.
Fornasiero EF, Bonanomi D, Benfenati F, Valtorta F.
Mol Microbiol. 2009 Jan;71(2):461-77. doi: 10.1111/j.1365-2958.2008.06538.x. Epub 2008 Nov 19.
Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones.
Bonanomi D*, Fornasiero EF*, Valdez G, Halegoua S, Benfenati F, Menegon A, Valtorta F.
*equal first authors
J Cell Sci. 2008 Nov 15;121(Pt 22):3757-69. doi: 10.1242/jcs.033803. Epub 2008 Oct 21.