The conventional detection of proteins by imaging employs fluorophores or antibodies directed at individual proteins. However, this methodology cannot be upscaled and employed in a high-throughput omics approach. The EU-funded IMAGEOMICS project aims to address this limitation through affinity probes that bind to specific peptide sequences located in more than one protein. Scientists will develop nanobodies that bind to such peptides and use them to label biological samples. The IMAGEOMICS strategy will provide information on the whole proteome of cells and tissues, paving the way for improved diagnostics for various diseases.
Silvio O. Rizzoli & Felipe Opazo, Universitaetsmedizin Goettingen – Georg-August Universitaet Goettingen – Stiftung Oeffentlichen Rechts, Germany
Doron Gerber, Bar-Ilan University, Israel
Steffen Frey, NanoTag Biotechnologies GmbH, Germany
Ilaria Testa, KTH Royal Institute of Technology, Sweden